Preprint

Carolin Körner, Jan-Hannes Schäfer, Bianca M. Escha , Kristian Parey, Stefan Walter, David Teis, Dovile Januliene, Oliver Schmidte, Arne Moellerb, Florian Fröhlich The levels of sphingolipids are crucial determinants of neurodegenerative disorders. Therefore, sphingolipid levels have to be tightly regulated. The Orm protein family and ceramides act as inhibitors in the rate-limiting step of sphingolipid […]

Sofia Doello, Dmitry Shvarev, Marius Theune , Jakob Sauerwein, Alexander Klon, Erva Keskin, Marko Boehm, Kirstin Gutekunst, and Karl Forchhammera The oxidative pentose phosphate (OPP) pathway is a fundamental carbon catabolic route for generating reducing power and metabolic intermediates for biosynthetic processes. In addition, its first two reactions form the OPP shunt, which replenishes the

Jan-Hannes Schäfer Lena Clausmeyer, Carolin Körner, Bianca M. Esch , Verena N. Wolf , Stefan Walter, Dovile Januliene, Arne Moeller, Florian Fröhlich Ceramides play a pivotal role as essential lipids, serving as foundational components for complex sphingolipids and potent signaling molecules. Ceramides are the products of the N-acylation of a sphingoid base and a CoA-activated

Dmitry Shvarev, Caroline König, Nicole Susan, Lars Langemeyer, Stefan Walter, Angela Perz, Florian Fröhlich, Christian Ungermann, Arne Moeller Cells depend on their endolysosomal system for nutrient uptake and downregulation of plasma membrane proteins. These processes rely on endosomal maturation, which requires multiple membrane fusion steps. Early endosome fusion is promoted by the Rab5 GTPase and