Theresa Gewering

Cotranslational assembly of membrane protein/nanoparticles in cell-free systems

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Roman Levin, Zoe Köck, Janosch Martin, René Zangl, Theresa Gewering, Leah Schüler, Arne Moeller, Volker Dötsch, Nina Morgner, Frank Bernhard Nanoparticles composed of amphiphilic scaffold proteins and small lipid bilayers are valuable tools for reconstitution and subsequent functional and structural characterization of membrane proteins. In combination with cell-free protein production systems, nanoparticles can be used […]

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Mechanism of multimodal substrate translocation in P-glycoprotein

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Theresa Gewering, Deepali Waghray, Kristian Parey, Joel Zapata, Pengyi Zhao, Hao Chen, Dovile Januliene, Ina L. Urbatsch, Arne Moeller, Qinghai Zhang P-glycoprotein (Pgp) is a highly dynamic ATP-binding cassette transporter that confers cancer multidrug resistance and mediates the bioavailability and pharmacokinetics of many drugs. Structural and biochemical data have provided insights into the binding of

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Neue Möglichkeiten für die Strukturbestimmungvon Membranproteinen

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Theresa Gewering, Arne Möller Membrane proteins establish the connection between the outside andthe inside of a cell. Even though 30 % of proteins in a cell are membraneassociated, their structural data is strongly underrepresented due tothe high flexibility and low purification yield. The resolution revolutionin cryo-EM opened up new opportunities to solve structures of dynamicmembrane

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